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Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen+ IV and NAD+ IV in healthy adults

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This appears to be a non-cholinergically facilitated action, as it is shared by its (+)-enantiomeric form, Posiphen ((+)-Phenserine tartrate) that lacks anticholinesterase activity, and is mediated post-transcriptionally via an iron response element within the 5-untranslated region (5UTR) of APP mRNA [79,80,81]