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Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10

RT-qPCR was performed with GAPDH as the internal control using the QuantStudio 1 instrument (Applied Biosystems, California, USA), and three replicates were performed

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Most methods employ 1,3-cyclohexanediones, especially dimedone, which already contain a carbonyl at the position that becomes C-5 in the final scaffold ( 2.4 Alternative synthetic routes for underexplored HHQ chemotypes 2.4.1 2-Oxo hexahydroquinolines 2.4.1.1 Enamine-mediated synthesis of 2-oxo HHQ derivatives Enamine-mediated strategies have emerged as versatile approaches for constructing HHQs derivatives, leveraging the high nucleophilicity of the enamine -carbon to facilitate acylation and cyclization