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doi: 10.3389/fphys.2018.00095 Received 25 October 2017 Accepted 29 January 2018 Published 14 February 2018 Volume 9 - 2018 Edited by Ali Mobasheri, University of Surrey, United Kingdom Reviewed by Felipe Simon, Universidad Andrs Bello, Chile

To the stirring solution mPEG 2000 -NH 2 (III, 103.00 g, 47.20 mmol, purchased from NOF Corporation, Japan) and anhydrous pyridine (Py, 80 mL, excess) were added under argon

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Together, they extend and amplify the pituitary's natural GH pulses a mechanism with direct relevance to perimenopause, during which growth hormone declines sharply, accelerating visceral fat accumulation, muscle loss, and bone density reduction