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Common features include: Small doses per spray, often used once or twice daily Gradual absorption rather than a sharp spike Effects that may feel steadier rather than intense Absorption can vary

It also improves blood vessel integrity through stimulation of collagen and elastin synthesis within vessel walls

The inhibition of these deleterious AT 1 receptor-mediated effects through ACE inhibitors or Ang receptor blockers (and more recently the direct renin inhibitor aliskiren) largely explains as to why the two former classes of antihypertensive drugs have become the gold standard of antihypertensive therapy