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Nature, 496 (7443), 101105

Our aim is to examine the potential of ferroptosis inhibition as a therapeutic strategy for AD

wustl.edu Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins As a physician-scientist, David Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage

524,525 In the liver, insulin suppresses the gluconeogenic enzymes PEPCK and G6 Pase via the Akt and FOXO pathways, 526,527 but resistance impairs this process, increasing glucose output