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The finding from the comprehensive AD epigenome-wide association study (EWAS) described 5246 CpG sites and 832 differentially methylated regions in 296 brain samples highlights the widespread changes in DNA methylation associated with AD (175)

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SIRS is driven by the innate immune system, leading to the release of pro-inflammatory cytokines such as IL-6, TNF-, and IL-1 [23]

doi: 10.3389/fendo.2014.00056 Received 20 March 2014 Accepted 07 April 2014 Published 22 April 2014 Volume 5 - 2014 Edited by Rosaria Meccariello, University of Naples Parthenope, Italy Reviewed by Rosanna Chianese, Second University of Naples, Italy