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The understanding of the mechanisms of gadolinium toxicity can help determine the clinical significance of gadolinium retention in tissues so that the risks of GBCA use for MRI can be better assessed

LC-MS/MS analysis Peptides were separated using a loading column (100 m 2 cm) and a C18 separating capillary column (100 m 15 cm) packed in-house with Luna 3 m C18(2) bulk packing material (Phenomenex, USA)

MTS cell viability assay NIT-1 cells were seeded at 10,000 cells per well in 96-well plate and incubated for 24 h before treatment

Niu X, Chen J, Gao J (2019) Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: focus on recent advances