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The coefficient of divergence was calculated to evaluate potential variations in this sense

For example, Cu deficiency has been shown to promote the aberrant hydrophobicity of mutant SOD1, contributing to the impaired interaction of SOD1 and its neuronal toxicity, and this effect could be reversed by the supplementation of Cu

In particular, nano-formulation strategiesincluding polymeric nanoparticles, lipid-based nanocarriers, nanoemulsions, and micellar systemshave shown promise in improving solubility, stability, and pharmacokinetic behavior