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In one, multiclinic, placebo controlled study employing an add-on design (adjunctive therapy), 144 patients who continued to suffer eight or more CPS per 8 weeks during an 8 week period of monotherapy with doses of either carbamazepine or phenytoin sufficient to assure plasma concentrations within the "therapeutic range" were randomized to receive, in addition to their original antiepilepsy drug (AED), either divalproex sodium or placebo

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A 2021 randomized trial in Nutrients found that 30 mg/day of saffron extract significantly improved hot flash severity and psychological symptoms including anxiety and depression in menopausal women