melanotic macule palate Pigmented Lesion on the Hard Pigmented Lesions of the Oral

The dentist will typically: Examine the spot carefully under good light, noting its size, location, shape, colour and edges

Melanin pigmentation has been reported to be most intense at the tips of the rete ridges [31, 34]

This chromatic variability not only reflects the genetic factors that regulate melanin synthesis by melanocytes and its subsequent transfer to adjacent keratinocytes but is also influenced by external factors such as trauma, inflammation, hormonal fluctuations, exposure to certain pharmacological agents, external agents that can pigment the mucosa, and radiation, all of which can induce an increase in melanin production

While most clinical studies investigating fibromyalgia have focused on melatonin rather than melanocortins specifically, the findings are relevant due to the overlapping pathways involved