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Given the up-regulation of several genes involved in mitochondrial transcription and translation, we investigated Mitochondrial Transcription Factor A ( TFAM ), a nuclear-encoded transcription factor essential for mtDNA transcription and replication [37], as a potential master regulator driving this program

Plasmacytoid dendritic cells in immunity

The diagnosis of MS is made according to clinical, radiological and, recently, biochemical criteria 3 and after diagnosis, early prediction of MS outcomes is a challenge because, until now, there is no strong candidate biomarker able to detect, early during disease course, those people with MS (pwMS) with subclinical neuronal damage and, therefore, more prone to develop clinical progression and functional impairment over time 4