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Thus, selenium supplementation should be carefully monitored in terms of the plasma selenium concentration to obtain the desired health benefits without any toxicological side effects

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Rai A, Tripathi P, Dwivedi S, Dubey S, Shri M, Kumar S, Tripathi PK, Dave R, Kumar A, Singh R, Adhikari B, Bag M, Tripathi RD, Trivedi PK, Chakrabarty D, Tuli R (2011) Arsenic tolerances in rice ( Oryza sativa ) have a predominant role in transcriptional regulation of a set of genes including sulphur assimilation pathway and antioxidant system

It is activated by caspase-1, and it forms pores in the plasma membrane, inducing cell lysis (Liu et al., 2016)