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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

The most authoritative and contemporary definition was articulated in 2002 by a joint Food and Agriculture Organization (FAO) and World Health Organization (WHO) expert consultation, which described probiotics as live microorganisms which, when administered in adequate amounts, confer a health benefit on the host (15)