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Specifically, AAV8 pVR59 was recently identified and demonstrated significantly higher efficacy of up to 10- to 100-fold lower doses needed, compared with an AAV1 vector based on Glybera, when delivered intramuscularly or intravenously, respectively, in mice with LPLD

Nuclei were further purified by centrifugation at 1,000 g for 5 min at 4 C through a 1 M sucrose cushion (3 mM MgAc, 10 mM Tris-HCl, pH 8) and then stained with a PCM1 antibody in nuclei stain buffer (DPBS, 1% BSA, 0.2% Igepal CA-630, 1 mM EDTA)

155 Hepatic Storage Function Because individual cells are unable to store a sufficient supply of energy-rich carbohydrate substrates, the liver serves as the major site for their storage

Bromopyridazinedione-mediated protein and peptide bioconjugation