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REIMAGINE 4 a 68-week efficacy and safety phase 3 trial of once-weekly CagriSema 2.4 mg/2.4 mg versus once-weekly tirzepatide 15 mg in 1,000 adults with type 2 diabetes inadequately controlled with metformin with or without an SGLT2 inhibitor

Excessive lipid metabolic reprogramming in OA significantly raises ferroptosis risk, so targeting lipid synthesis, transport, and degradation represents a promising upstream approach to reducing ferroptotic damage

For researchers considering IGF1 LR3 for their studies, careful protocol design, appropriate safety tracking, and thorough records are essential

2.4 mg was the dose advanced into Phase 3 because the efficacy/tolerability ratio peaked there