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Increased Metabolism Your metabolism relies on multiple systems working in harmony, and one small shift can have big consequences

The Phe residue that moves between the open and closed conformation is displayed in orange and the residue forming a hydrogen bond with the ligand is displayed in green

Other studies have shown that enhancing SIRT1 activity using pharmacological agents can reduce different types of hearing loss, indicating that SIRT1 is a promising target for hearing protection [22, 23]