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When circulating levels fall below optimal, the downstream effects are real and measurable: fatigue, poor concentration, slowed metabolism, and reduced resilience to illness

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Crystallisation was performed by sitting-drop vapour diffusion at the IBMB Automated Crystallography Platform ( Optimal crystals, with one protomer in the asymmetric unit, formed at 20 C with protein at 16 mg/mL, using a reservoir solution containing 0.1 M Bis-Tris propane pH 6.5, 0.2 M sodium sulphate, 22% polyethylene glycol 3350

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