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Chronic stress, environmental toxins, diets low in nutrients but high in inflammatory triggers, sleep deprivation, smoking, sugar, excess alcohol, and other stressors slowly deplete glutathione levels

After incubation, the cells were stimulated using 1 g/mL LPS, and the stimulated cells were then treated with non-toxic concentrations of APE, GSH and DEX as a reference control

Moreover, HPA axis dysregulation is implicated in many physical and psychiatric disorders [46] that can be triggered or exacerbated by stress, and related neuroimaging alterations are not disease-specific