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While that may sound destabilizing, it points to a conformational shift in DNA duplex architecture that could facilitate transcription while preventing hardening of the genome that often accompanies age and oxidative stress [37]

Promotion in progress 54 instead of 69

However, the role of mitophagy regulators such as PINK1/PRKN, BNIP3, and NIX in pancreatic tumorigenesis and progression is dynamic and intricate, as demonstrated in transgenic PDAC mouse models [53, 58]