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Last reviewed: June 7, 2026 Last updated: June 7, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Remember that clinical trials failed to demonstrate statistically significant weight loss in the largest study, leading to development termination in 2007

While this trial showed trends toward fat loss in the treatment groups, the primary endpoint of statistically significant weight reduction compared to placebo was not consistently achieved across all dose groups, and effect sizes were more modest than hoped

Expression of Cyp27a1 was not altered among the 4 animal groups (Fig