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doi: 10.1038/s41375-022-01613-1 3 HochmanMJDeZernAE

LiuMPengRTianCShiJMaJShiRet al

From a mechanistic perspective, evidence shows that NMN treatment upregulates SIRT1 expression, regulates the MSCs in aging bone marrow through the SIRT1 pathway, and thus promotes bone formation and reduces adipogenesis [49]

Participants spent an average of 2.7 hours outdoors each day, and daily pollen counts ranged from less than 20 grains/m 3 to more than 100 grains/m 3 during the treatment period