This finding suggests that methylmalonic acid and homocysteine levels can be early markers for tissue vitamin B 12 deficiency, even before hematologic manifestations occur
Although some animals are very sensitive to biotin deficiency during pregnancy, a link between biotin deficiency and adverse effects in the mother and the developing fetus has not been observed in humans
These extremely rare side effects include: Reactive thrombocytosis during the first week of use in megaloblastic anaemia Hypersensitivity reactions including: rash, itching, exanthema, antibodies to HYDR0XOCOBALAMIN-transcobalamin II Anaphylaxis Hypokalaemia Headache, paraesthesia, tremor Irregular heartbeat (arrhythmias secondary to hypokalaemia) Nausea Vomiting Diarrhoea Fever, chills, hot flushes, dizziness, malaise, pain and / or swelling at the injection site Acne Abnormal colouration of the urine (chromaturia) B12 injections work quickly
Neurodegenerative diseases : Some doctors use NAD therapy to support patients with Parkinsons or Alzheimers disease, and insurance may cover a portion if it is deemed medically necessary