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These findings suggest that while FOXO4 is involved in the senescence pathway, it also plays a role in maintaining the viability of senescent Leydig cells by suppressing their apoptotic response, which could contribute to the accumulation of senescent cells [1]

The Spalt transcription factors regulate cell proliferation, survival and epithelial integrity downstream of the Decapentaplegic signalling pathway

2b), we interrogated SPIED, finding a large number (393) of positively associated compounds, with 156 in common with those obtained using our broad oligodendroglial signature (Fig