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Multifunctional combination platforms, capitalizing on high loading capacities, permit co-delivery of PROTACs with chemotherapeutics, epigenetic modifiers, or immunomodulators, thereby overcoming resistance through synergistic multitarget engagement [295]

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Researchers are investigating alternative nanoparticle systems, including polymer-based nanoparticles, inorganic nanoparticles, hybrid nanoparticles, and peptide nano-assemblies, to overcome these limitations