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These findings suggest that the combination of small molecule NNMT inhibitors with other nutritional supplements, such as the precursors of NAD + , may have the potential to enhance the efficacy of treatment for MetS and minimize the side effects caused by high pharmacological dosages (Roberti et al., 2021)

Among them are GLP-1 agonists, DPP-4 inhibitors, and SGLT2 inhibitors

Autophagosomes formed during autophagy were stained with the MDC staining kit, 4T1 cells were seeded in CLSM dishes for 4 groups: Control (untreated), Bi 2 S 3 -3BP (Bi: 60 g mL 1 , 3BP: 10 g mL 1 ), Bi 2 S 3 (Bi: 60 g mL 1 ) + X-ray, and Bi 2 S 3 -3BP (Bi: 60 g mL 1 , 3BP: 10 g mL 1 ) + X-ray, respectively

After injection, the needle was left in place for additional 10 min to avoid drug reflux