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Primary endpoint: GSH concentration in venous umbilical cord blood erythrocyte in response to NAC supplementation GSH concentrations in venous cord blood did not differ between NAC and placebo arms, whether FAS ( P 0.38) or PP ( P 1.0) populations were considered

Subsequent efforts to improve the therapeutic index led to the development of JHU083, an orally bioavailable DON prodrug, which has thus far been evaluated only in preclinical models [168]

The option of using single dose vaccines, which do not require thimerosal, is not feasible for some countries because of limits in the production of single-dose vaccines and lack of infrastructure for the transportation and storage of single-dose vials in a cold-chain system