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The depletion of transmembrane 7 superfamily member 2 (TM7SF2), a key regulator of cholesterol biosynthesis, results in the increased expression of FA catabolic enzymes accompanied by decreased lipid accumulation, autophagy, and tissue injury in mice exposed to endotoxin ( de novo sphingolipid biosynthesis is essential for autophagy induction in macrophages, which plays a protective role by clearing excess lipids from LDs through the turnover of ORMDL sphingolipid biosynthesis regulator 1 (ORMDL1) protein, a negative regulator of serine palmitoyl-CoA transferase activity (Wang et al., 2015b)

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4.4 Oxidative stress and endothelial cells Vascular endothelial cells not only function as a selective barrier but also synthesize and secrete diverse active molecules, participate in inflammatory processes, and regulate vascular elasticity