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Ultimately, the time required for an organisms phenotype to change as a result of plasticity mechanisms is dependent upon a biological sensor detecting the environmental change plus the time to turn on or off a gene or protein expression to create a modified phenotype

Some regression is normal when discontinuing any performance-enhancing therapy

Inclusion Criteria Original studies (randomized controlled trials, cohort studies, experimental studies, or observational designs) evaluating the effects of prolotherapy (dextrose prolotherapy) in patients with CLBP

While animal and early human studies indicate possible roles in adipose regulation, the compound remains under investigation across several scientific fields