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Another peptide with promise: LL-37 is an antimicrobial peptide involved with our innate immune system of defense against microbial invasion and decreases gut permeability via improved tight junctions (claudin, occludins)

(4) + Leucine and nicotinic acid works on the same mechanisms as caloric restriction and exercise to activate the SIRT/NAD+/AMPK axis to improve vasodilation, lower lipids, and decrease inflammation and foam cell production

The chronic activation of immune cells, persistent secretion of profibrotic mediators, and continuous recruitment of immune cells to the injury site create a self-sustaining cycle of inflammation and fibrosis

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