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Al fijarse al dominio extracelular, provoca autofosforilacin de residuos de tirosina y reclutamiento de sustratos IRS-1/IRS-2, disparando dos rutas principales: la va PI3K/Akt, asociada a supervivencia celular, captacin de glucosa e inhibicin de la apoptosis, y la va MAPK/ERK, vinculada a proliferacin y crecimiento