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Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]

Pomegranate-derived exosome-like nanovesicles alleviate Binge alcohol-Induced leaky gut and liver injury

Now, amidst growing controversy, a federal judge has taken the FDAs stance one step further and has ordered Flawless Beauty, a New Jersey company selling unapproved skin-whitening products (including skin-lightening injections), to stop distributing its due to serious health risks associated with the injections

10.1039/c5ra13559a RSC Adv