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Two-thirds of all Wilson disease patients experience physiatric problems such as depression and anxiety, which often present before neurological and liver-related symptoms

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A lone pair on a carbon atom (C 35 , likely adjacent to the electron-deficient boron) donates into a * anti-bonding orbital (C 27 -C 48 ) with a very high E 2 value of 44.37 kcal.mol 1

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