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While detailed evidence of blood glucose reduction from direct animal models or systematic measurements in clinical studies is lacking, other studies in the literature highlight the beneficial effects of ZO on hyperglycemia in diabetic animal models (Alshathly 2019)

Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism

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15 Zhao, Z., et al