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Gossel G, Hogan T, Cownden D, Seddon B, Yates AJ

SARS-CoV-2 infection dysregulates host iron (Fe)-redox homeostasis (Fe-R-H): role of fe-redox regulators, ferroptosis inhibitors, anticoagulants, and iron-chelators in COVID-19 control

SLC25A11 belongs to the solute carrier family 25 (SLC25), which encompasses 53 known carrier proteins that play critical roles in regulating cellular metabolism and physiological processes (reviewed in Kunji et al., 2020)

Furthermore, a 2-year, double-blind, randomized, placebo-controlled therapeutic trial in 158 healthy siblings of hyperhomocysteinemic patients with premature atherothrombotic disease folic acid plus vitamin B 6 treatment was associated with a decreased occurrence of abnormal exercise electrocardiography tests, which is consistent with a decreased risk of atherosclerotic events (Vermeulen et al, 2000)