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7 Limitations and challenges Most recent studies on ferroptosis in ophthalmology have focused on RPECs or RGCs, but studies on the ability of Mller cells, vascular endothelial cells, PRs, and even corneal endothelial cells to induce ferroptosis are lacking, and comprehensive single-cell maps are lacking, leaving unresolved questions like the variations in the susceptibility of various cell types to ferroptosis, which can be parallel or mutually causal with apoptosis, necrosis, and pyroptosis (414)

This upregulation results in higher self-renewal capabilities, motility and altered epithelial-to-mesenchymal transition (EMT) activator expression (72)

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