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Description

Aljohani, A

10.1136/bmj.320.7244.1240 40

Factors that increase leakage risk include injecting too quickly, withdrawing the needle at an angle, and moving the injection site immediately after administration

gentle swirling is sufficient if mixing is required Minimise the number of times the vial is accessed, as repeated needle punctures increase contamination risk Label the vial clearly with the date and time of reconstitution, and with the sponsor-validated beyond-use date Follow all additional handling instructions specified in the IMP label or protocol These measures help to slow the degradation processes described above