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10.1016/j.arr.2021.101364 105 MajumderP.HsuT

PubMed PMID: 32481558

This partly explains the higher morbidity and mortality rates observed in COVID-19 patients with preexisting diabetes 307

Mechanistically, -Syn oligomers interact with mitochondrial respiratory chain complex I, impairing its function, leading to mitochondrial membrane potential depolarization, and promoting the release of proapoptotic factors into the cytoplasm