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BMJ 374:n1648 Cysique LA, Jakabek D, Bracken SG, Allen-Davidian Y, Heng B, Chow S, Dehhaghi M, Pires AS, Darley DR, Byrne A, Phetsouphanh C, Kelleher A, Dore GJ, Matthews GV, Guillemin GJ, Brew BJ (2022) Post-acute Covid-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study

In response to the toxins, macrophages release inflammatory chemicals and begin to recruit more immune-system cells, which in turn release more inflammatory chemicals as well as protease enzymes that degrade the extracellular matrix (Fischer 2011

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Furthermore, M1 macrophages exhibit significant metabolic reprogramming during activation, including enhanced glycolysis and alterations in the TCA cycle