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Intriguingly, LL-37 also has anti-inflammatory properties in certain contexts, making it a dual-natured molecule

This trend starts around the same time as fentanyl but really takes off in 2019

J Neurochem 134:720 Orhan N, Ugur Yilmaz C, Ekizoglu O, Ahishali B, Kucuk M, Arican N, Elmas I, Grses C, Kaya M (2016) Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain injury