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Simultaneously, the process of aging precipitates a phenomenon known as inflammaging, characterized by a chronic low-grade inflammatory condition mediated by heightened concentrations of IL-6, TNF-, and CRP, which disrupt anabolic signaling pathways, including mTOR, and inhibit MPS (12, 90)

In the canonical pathway of pyroptosis, intracellular pattern recognition receptors (PRRs) recognize PAMPs (Pathogen-Associated Molecular Patterns) or Damage-Associated Molecular Patterns (DAMPs), which can activate NLR family pyrin domain-containing 3 (NLRP3) and assemble with pro-caspase-1 and adaptor protein ASC to form inflammasomes

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Additionally, the study revealed for the first time that BMI1, a member of the Polycomb Repressive Complex 1, the most essential family of proteins responsible for epigenetic regulation, was overexpressed following nano-formulation treatment