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Naringenin attenuates CC l 4 -induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats

ER and Golgi apparatus were stained using ER-Tracker Red (Fisher Scientific 11584746) diluted 1:2000 and anti-Giantin (BioLegend 908701) 135 diluted 1:500

Although non-selective targeting of isozymes could result in undesired side effects, the existence of PDE5-Is with dual impacts on factors contributing to the same pathological condition, particularly multi-factorial diseases, could potentially offer an advantage over the traditional single target-one disease approach