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Hal ini dapat meningkatkan risiko terjadinya resistensi insulin dan diabetes tipe 2

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Although antioxidant defense mechanisms [glutathione peroxidase (GPx), peroxiredoxin (Prx), and catalase (Cat)] work to neutralize ROS, their capacity is often overwhelmed in chronic pain states

The significance of the additional FBXO22-NSD2 interaction surface, which is not interacting with the compound, was further assessed in a proximity-based Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay which uses a biotinylated version of the FBXO22 FIST domain and His-tagged NSD2 PWWP1