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The primary objective of this review is to elucidate the mechanisms by which adrenal hormone imbalance induces oxidative stress and investigate the potential contributions of nutritional antioxidants in mitigating such imbalances

For example, methapyriline increases liver weight and the number of hepatocyte mitochondria in treated mice, with development of hepatotoxicity and liver neoplasia probably secondary to oxidative damage (Powell et al

As such, complex I inhibitors like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or rotenone show preferential cytotoxicity to the DA neurons (Mizuno et al., 1987)

doi: 10.2174/1573399818666220418080959