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Disagreements about the data were resolved through consensus with a third researcher

As a result, newly synthesized NRF2 accumulates in the cytoplasm, translocates to the nucleus, heterodimerizes with small Maf proteins, and binds to antioxidant response elements (AREs) in the promoter regions of target genes (Ishii et al., 2022

The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway