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10.1007/s00424-010-0862-9 35 DuniA.LiakopoulosV.RoumeliotisS.PeschosD.DounousiE

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Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

Add the chicken broth, cream cheese, and heavy cream and heat over medium heat, whisking until smooth