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Hemoglobin Heme next moves into the cytosol where it is linked to the heme pocket of globin in a precise and stable position that permits binding of oxygen to the heme

Science 298 , 17901793 (2002)

Our analysis revealed that ferroptosis-related genes in excitatory neurons from human brains are mostly downregulated at an early clinical stage of AD, while they are upregulated at a later clinical stage of the disease relative to early stage (Table 1)