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To further understand the difference in 5mC methylation patterns in OA G20 under stress, we conducted ONT sequencing (R9.4.1 MinIon flow cells) of samples collected from biofilms exposed to 30 M-Cu ion concentrations and then compared them to the control (0 M-Cu)

However, some individuals might not see the desired results

These findings demonstrate that aging is not a unilateral loss of stemness but rather a rewiring of stem cellniche interactions

In some embodiments, the agents encompassed by the present invention can be formulated using peptides and/or other conjugates to increase the penetration of cells (e.g., macrophages and other immune cells)