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These improvements in cardiovascular risk markers, combined with enhanced insulin sensitivity and glucose metabolism, suggest tesofensine may provide comprehensive metabolic benefits for obese individuals with comorbid metabolic conditions

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The reaction mixture was incubated at 30 C and the consumption of NADH was monitored continuously for 60 min with a TECAN M200 plate reader by measuring the absorbance at 340 nm

The peptide also activates alternative angiogenic pathways including VEGF-independent routes via Src-caveolin-1-eNOS signaling, providing redundant mechanisms for vascular regeneration