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However, when inflammation becomes chronic, it can turn from a helpful response into a harmful one, contributing to the development of chronic diseases such as heart disease, cancer, and rheumatoid arthritis

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Additional preclinical studies looking at the safety and efficacy of the combined treatment with pramlintide/phentermine and pramlintide/sibutramine was evaluated in a randomized placebo-controlled study with 244 obese or overweight nondiabetic subjects (203)