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Vitamin B12 plays a foundational role in red blood cell production, neurological function, DNA synthesis, and energy metabolism

However, the current available antibody assay has low sensitivity and studies have found that antibodies are only detectable in 4060% of pernicious anaemia cases, so a negative test cannot categorically exclude pernicious anaemia[18,19]

When administered following clinical assessment and appropriate dosing, IV B-complex is generally well tolerated